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Se han descrito numerosas alteraciones del sueño inducidas por la epilepsia nocturna. La gabapentina (GBP), es utilizado como adyuvante o como tratamiento monoterapéutico ya que induce una mejoría significativa en pacientes con convulsiones focales parciales o secundariamente generalizadas. En modelos animales experimentales de epilepsia con pentilenetetrazol (PTZ), la GBP protege contra las convulsiones generadas. El objetivo de este trabajo fue investigar su eficacia para proteger contra las alteraciones motoras y del sueño provocadas por crisis convulsivas. Se realizaron estudios poligráficos en ratas wistar macho, separadas en 4 grupos. Tras la administración de solución salina, se realizó un registro control en cada grupo. Posteriormente, un grupo recibió 50 mg/kg de PTZ, mientras que los otros tres grupos recibieron 15, 30 o 60 mg/kg de GBP, 30 minutos antes de la administración de PTZ. Después de la administración de PTZ, se observaron las manifestaciones electrofisiológicas y conductuales que caracterizan a las crisis convulsivas. Además, los estados de vigilancia se alteraron significativamente, incrementándose la cantidad de vigilia, mientras que el sueño se inhibió durante un período de tiempo. La administración de dosis crecientes de GBP, tendió a inhibir la presencia de conductas motoras anormales, facilitando la presencia de sueño
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Derechos de autor 2022 Fructuoso Ayala Guerrero, Graciela Mexicano Medina, Angel Guerrero, Carlos Alberto Gutiérrez Chávez, Legna Alejandra Lazo Sánchez, Erik Leonardo Mateos Salgado