Our aim in this study was to analyze the psychometric characteristics of the Manheim Interview of Social Support (MISS) in Argentina. The adapted version of the MISS was administered to a sample of 198 Argentine participants. The local version of the MISS exhibited a stable configuration. We corroborated that, the inclusion of the kin/nonkin dimension was supported. Finally, low correlations with the Beck Depression Inventory and the UCLA Loneliness Scale suggest the convenience of a complementary evaluation of the subjective and cognitive aspects of support if one were to predict variables associated with health and illness. In conclusion, the MISS provides a complete description of the social network and its functions, which is important for prevention and intervention programs.